Molecules
(Feb 2022)
Synthesis of (<i>+</i>)<i>-</i>(<i>R</i>)-Tiruchanduramine
Zahraa S. Al-Taie,
Barbara Bartholomew,
Christopher Cartmell,
Richard T. Froom,
Russell G. Kerr,
Rolf Kraehenbuehl,
Patrick J. Murphy,
Robert J. Nash,
Yana B. Penkova,
Alexander van Teijlingen
Affiliations
Zahraa S. Al-Taie
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad 10072, Iraq
Barbara Bartholomew
The Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Aberystwyth SY23 3DA, UK
Christopher Cartmell
Department of Chemistry and Biomedical Sciences, DRC, 550 University Avenue, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada
Richard T. Froom
School of Natural Sciences (Chemistry), Bangor University, Bangor LL57 2UW, UK
Russell G. Kerr
Department of Chemistry and Biomedical Sciences, DRC, 550 University Avenue, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada
Rolf Kraehenbuehl
Centre for Environmental Biotechnology, Bangor University, Deiniol Rd., Bangor LL57 2UW, UK
Patrick J. Murphy
School of Natural Sciences (Chemistry), Bangor University, Bangor LL57 2UW, UK
Robert J. Nash
The Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Aberystwyth SY23 3DA, UK
Yana B. Penkova
The Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Aberystwyth SY23 3DA, UK
Alexander van Teijlingen
School of Natural Sciences (Chemistry), Bangor University, Bangor LL57 2UW, UK
DOI
https://doi.org/10.3390/molecules27041338
Journal volume & issue
Vol. 27,
no. 4
Abstract
Read online
The absolute stereochemistry of the marine alkaloid (+)-(R)-tiruchanduramine was established via a convergent total synthesis in six steps and 15.5% overall yield from Fmoc-D-Dab(Boc)-OH.
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