Trends in Simple and Complex Appendicitis in Children and the Potential Correlation to Common Viral Pathogens—A Retrospective Cohort Study between 2010 and 2019 in The Netherlands
Sarah-May M. L. The,
Paul van Amstel,
Sophie M. Noordzij,
Roel Bakx,
Taco. S. Bijlsma,
Joep. P. M. Derikx,
L. W. Ernest van Heurn,
Martijn van der Kuip,
Ramon R. Gorter
Affiliations
Sarah-May M. L. The
Department of Pediatric Surgery, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam & Vrije Universiteit Amsterdam, 1105 AZ Amsterdam, The Netherlands
Paul van Amstel
Department of Pediatric Surgery, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam & Vrije Universiteit Amsterdam, 1105 AZ Amsterdam, The Netherlands
Sophie M. Noordzij
Department of Pediatric Surgery, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam & Vrije Universiteit Amsterdam, 1105 AZ Amsterdam, The Netherlands
Roel Bakx
Department of Pediatric Surgery, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam & Vrije Universiteit Amsterdam, 1105 AZ Amsterdam, The Netherlands
Taco. S. Bijlsma
Department of Surgery, Northwest Hospital, 1815 JD Alkmaar, The Netherlands
Joep. P. M. Derikx
Department of Pediatric Surgery, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam & Vrije Universiteit Amsterdam, 1105 AZ Amsterdam, The Netherlands
L. W. Ernest van Heurn
Department of Pediatric Surgery, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam & Vrije Universiteit Amsterdam, 1105 AZ Amsterdam, The Netherlands
Martijn van der Kuip
Department of Pediatric Infectious Diseases and Immunology, Emma Children’s Hospital, Amsterdam UMC, Amsterdam Infection & Immunity Institute, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
Ramon R. Gorter
Department of Pediatric Surgery, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam & Vrije Universiteit Amsterdam, 1105 AZ Amsterdam, The Netherlands
The aim of this study was to evaluate the annual, seasonal and monthly trends in children with simple and complex appendicitis and their correlation to common viral pathogens in the Netherlands. A consecutive multicenter retrospective cohort study was performed between 2010 and 2019 including children (p p = 0.011), but the variance was regarded as not relevant (p = 0.026) and simple appendicitis with Adenovirus NON 40.41 (R = 0.332, 95%CI 0.019–0.586, p = 0.039), but these correlations did not remain significant after a Bonferroni correction (p < 0.003). In conclusion, we found no relevant seasonal variation for simple or complex appendicitis, nor positive correlation with common viral pathogens.
