Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department
Ilaria Dafne Papasidero,
Gabriele Valli,
Dario Marin,
Alberto Del Sasso,
Antonio De Magistris,
Elisa Cennamo,
Silvia Casalboni,
Francesca De Marco,
Roberta Rocchi,
Brice Ndogmo Beumo,
Valeria Cusani,
Mariarosa Gaudio,
Oliver Hartmann,
Andreas Bergman,
Maria Pia Ruggieri,
Salvatore Di Somma
Affiliations
Ilaria Dafne Papasidero
Postgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, Italy
Gabriele Valli
Department of Emergency Medicine, San Giovanni Addolorata Hospital, 00184 Rome, Italy
Dario Marin
Postgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, Italy
Alberto Del Sasso
Postgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, Italy
Antonio De Magistris
Postgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, Italy
Elisa Cennamo
Postgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, Italy
Silvia Casalboni
Postgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, Italy
Francesca De Marco
Department of Emergency Medicine, San Giovanni Addolorata Hospital, 00184 Rome, Italy
Roberta Rocchi
Postgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, Italy
Brice Ndogmo Beumo
Postgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, Italy
Valeria Cusani
Postgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, Italy
Mariarosa Gaudio
Department of Clinical Pathology, San Giovanni Addolorata Hospital, 00184 Rome, Italy
Oliver Hartmann
SphingoTec, 16761 Hennigsdorf, Germany
Andreas Bergman
SphingoTec, 16761 Hennigsdorf, Germany
Maria Pia Ruggieri
Department of Emergency Medicine, San Giovanni Addolorata Hospital, 00184 Rome, Italy
Salvatore Di Somma
Postgraduate School of Emergency Medicine, Sapienza University of Rome, 00185 Rome, Italy
Background and Objectives: In order to accelerate the risk stratification of patients referred to the Emergency Department (ED) with interstitial pneumonia, it could be useful to provide new and effective laboratory tests for use. The aim of our study was to evaluate the prognostic role of two biomarkers, bio-adrenomedullin (Bio-ADM) and proenkephalin (penKid), in patients with interstitial pneumonia (IP) at ED admission. Materials and Methods: In 153 consecutive patients with IP, both from COVID-19 or non-COVID-19 etiology, we measured, in a prospective observational manner, penKid and Bio-ADM at ED admission and after 24 h. In order to evaluate patient outcomes, 30-day follow-ups were also performed. The endpoints were 24 h, 10-day, and 30-day mortality. Results: Both biomarkers were shown to be good predictors of adverse events at 30 days, with Bio-ADM outperforming penKid. Bio-ADM was linked with 24 h and 10-day patient mortality. Moreover, PenKid was related to parameters defining worsening kidney function. Conclusions: Both in patients with COVID-19 or non-COVID-19 interstitial pneumonia at ED admission, Bio-ADM and penKid were good predictors of patient mortality. To evaluate these two biomarkers could be considered to be useful during the first evaluation in the ED when integrated with clinical scores.
