Study of the state of hypoxia of the renal tissue in patients with oxalate urolithiasis

Abstract

Objective: tto determine the contribution of key metabolites and enzymes, taking into account the polymorphism of the latter, in the development of oxalic urolithiasis.Materials and methods: the study included 72 patients (30 men and 42 women) with previously confirmed oxalic urolithiasis. Blood samples were taken from patients previously divided into groups depending on the stage of treatment. Lactate, lactate dehydrogenase, protein-bound hydroxyproline, homocysteine, malondialdehyde, and glutathione peroxidase in blood were determined, the polymorphism of the MTHFR gene was studied.Results: the change in the concentration of the studied markers in the serum of different groups of patients suffering from oxalate urolithiasis was found; differences in the polymorphism of the MTHFR gene responsible for the metabolic transformations of homocysteine in the organism of patients with oxalate urolithiasis were established.Conclusion: one of the chains of the development of oxalate urolithiasis was studied on the example of markers of hypoxia of the renal tissue.

Keywords

• oxalate urolithiasis
• hypoxia
• glutathione peroxidase
• lactate
• homocysteine
• protein-bound hydroxyproline