Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathways

Yilan Zhen; Carlie L. Cullen; Raphael Ricci; Benjamin S. Summers; Sakina Rehman; Zubair M. Ahmed; Antoinette Y. Foster; Ben Emery; Robert Gasperini; Kaylene M. Young

doi:10.1038/s42003-022-03470-1

Communications Biology (May 2022)

Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathways

Yilan Zhen,
Carlie L. Cullen,
Raphael Ricci,
Benjamin S. Summers,
Sakina Rehman,
Zubair M. Ahmed,
Antoinette Y. Foster,
Ben Emery,
Robert Gasperini,
Kaylene M. Young

Affiliations

Yilan Zhen: Menzies Institute for Medical Research, University of Tasmania
Carlie L. Cullen: Menzies Institute for Medical Research, University of Tasmania
Raphael Ricci: Menzies Institute for Medical Research, University of Tasmania
Benjamin S. Summers: Menzies Institute for Medical Research, University of Tasmania
Sakina Rehman: Department of Otorhinolaryngology Head and Neck Surgery, School of Medicine, University of Maryland
Zubair M. Ahmed: Department of Otorhinolaryngology Head and Neck Surgery, School of Medicine, University of Maryland
Antoinette Y. Foster: Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University
Ben Emery: Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University
Robert Gasperini: Menzies Institute for Medical Research, University of Tasmania
Kaylene M. Young: Menzies Institute for Medical Research, University of Tasmania

DOI: https://doi.org/10.1038/s42003-022-03470-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 21

Abstract

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Protocadherin 15 promotes lamellipodial and filopodial dynamics in oligodendrocyte progenitor cells by regulating Cdc42-Arp2/3 activity, but also suppresses ERK1/2 phosphorylation to reduce proliferation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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