PLoS ONE (Jan 2016)

Diagnostic Accuracy of Lateral Flow Urine LAM Assay for TB Screening of Adults with Advanced Immunosuppression Attending Routine HIV Care in South Africa.

  • Yasmeen Hanifa,
  • Katherine L Fielding,
  • Violet N Chihota,
  • Lungiswa Adonis,
  • Salome Charalambous,
  • Alan Karstaedt,
  • Kerrigan McCarthy,
  • Mark P Nicol,
  • Nontobeko T Ndlovu,
  • Faieza Sahid,
  • Gavin J Churchyard,
  • Alison D Grant

DOI
https://doi.org/10.1371/journal.pone.0156866
Journal volume & issue
Vol. 11, no. 6
p. e0156866

Abstract

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We assessed the diagnostic accuracy of Determine TB-LAM (LF-LAM) to screen for tuberculosis among ambulatory adults established in HIV care in South Africa.A systematic sample of adults attending for HIV care, regardless of symptomatology, were enrolled in the XPHACTOR study, which tested a novel algorithm for prioritising investigation with Xpert MTB/RIF. In this substudy, restricted to participants with enrolment CD495% irrespective of diagnostic reference standard, CD4 stratum, or whether grade 1 or grade 2 cut-off was used.Sensitivity of LF-LAM is too low to recommend as part of intensified case finding in ambulatory patients established in HIV care.