Evaluation of the Possible anti oxidant Effect of Omega-369 against cisplatin - Induced Nephrotoxicity in mice

Abstract

Background: Nephrotoxicity is the adverse effect of substances on renal function .one of These substances is cisplatin. cisplatin (CP) treatment has long been linked to Nephrotoxicity due to oxidative stress mechanisms. Triple omega 3-6-9 is a combination of unsaturated fatty acids (UFAs)With omega-3 (n-3) and omega-6 (n-6) being polyunsaturated fatty acids (PUFAs) and omega-9 (n-9) being a monounsaturated fatty acid (MUFA). Aim : the reason for this study was to discover if omega-369 fatty acids could protect the kidney from the effects of cisplatin. Methods: Thirty-five albino male mice were allocated to one of five groups. group 1 received liquid paraffin, group 2 received cisplatin (10 mg/kg) by single intraperitoneal injection, group 3 received omega-369 (50 mg/kg) orally, group 4 received omega-369 (100 mg/kg) orally mice of group 5 received vit E(100 mg/kg) orally The mice were treated with Omega 369, vit e, and liquid paraffin once daily by oral gavage for 7 days Results: Group 2 had significantly lower levels of glutathione peroxidase and superoxide dismutase than group1, significantly greater levels of malondialdehyde, serum urea nitrogen and serum creatinine (p<0.05) , glutathione peroxidase and superoxide dismutase level significant increase in group3,4 and 5. whereas malondialdehyde, serum urea nitrogen an creatinine levels were significantly decrease in groups 3, 4, and 5 when compared with group 2 (p<0.05). Conclusion: Omega-369 fatty acids exhibit anti oxidative effects so reduce the risk of cisplatin-induced kidney injury.

Keywords

• Cisplatin, nephrotoxicity, omega 369 ,oxidative stress