Menopause Review (Dec 2010)

Polimorfizm hOGG1 Ser326Cys i XRCC1 Arg399Gln genów naprawy DNA przez wycinanie zasad azotowych (BER) u kobiet w wieku pomenopauzalnym chorych na raka endometrium

  • Hanna Romanowicz-Makowska,
  • Beata Smolarz,
  • Bożena Góralczyk,
  • Kinga Mroziewicz,
  • Ireneusz Połać,
  • Krzysztof Szyłło,
  • Andrzej Kulig

Journal volume & issue
Vol. 14, no. 6
pp. 366 – 370

Abstract

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Background: Single nucleotide polymorphisms in DNA base excision repair (BER) system such as: hOGG1and XRCC1 genes have been extensively studied in the association with various cancers. Material and methods: In the present study hOGG1 Ser326Cys and XRCC1 Arg399Gln gene polymorphismsin endometrial cancer patients and controls were investigated. Results: There were no significant (p > 0.05) differences in the frequencies of genotypes or alleles of hOGG1genes between endometrial cancer women and controls. However, the frequency of the XRCC1 399Gln allelewas significantly greater in endometrial cancer subjects as compared with controls (p = 0.035) [OR 1.25 (95% CI1.02 to 1.55). The distributions of genotypes and alleles of the hOGG1 and XRCC1 genes were not significantlyassociated with the different grades of endometrial cancer (p > 0.05). Conclusion: This study suggested that XRCC1 Arg399Gln polymorphism may play an important role in endometrialcancer development in the Polish population.

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