Nature Communications (Jul 2018)
The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis
- Wenguang Yin,
- Hyun-Taek Kim,
- ShengPeng Wang,
- Felix Gunawan,
- Lei Wang,
- Keishi Kishimoto,
- Hua Zhong,
- Dany Roman,
- Jens Preussner,
- Stefan Guenther,
- Viola Graef,
- Carmen Buettner,
- Beate Grohmann,
- Mario Looso,
- Mitsuru Morimoto,
- Graeme Mardon,
- Stefan Offermanns,
- Didier Y. R. Stainier
Affiliations
- Wenguang Yin
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- Hyun-Taek Kim
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- ShengPeng Wang
- Department of Pharmacology, Max Planck Institute for Heart and Lung Research
- Felix Gunawan
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- Lei Wang
- Department of Pharmacology, Max Planck Institute for Heart and Lung Research
- Keishi Kishimoto
- Laboratory for Lung Development, RIKEN Center for Developmental Biology
- Hua Zhong
- Departments of Pathology and Immunology and Molecular and Human Genetics, Integrative Molecular and Biomedical Sciences Program, Baylor College of Medicine
- Dany Roman
- Departments of Pathology and Immunology and Molecular and Human Genetics, Integrative Molecular and Biomedical Sciences Program, Baylor College of Medicine
- Jens Preussner
- Max Planck Institute for Heart and Lung Research, ECCPS Bioinformatics and Deep Sequencing Platform
- Stefan Guenther
- Max Planck Institute for Heart and Lung Research, ECCPS Bioinformatics and Deep Sequencing Platform
- Viola Graef
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- Carmen Buettner
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- Beate Grohmann
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- Mario Looso
- Max Planck Institute for Heart and Lung Research, ECCPS Bioinformatics and Deep Sequencing Platform
- Mitsuru Morimoto
- Laboratory for Lung Development, RIKEN Center for Developmental Biology
- Graeme Mardon
- Departments of Pathology and Immunology and Molecular and Human Genetics, Integrative Molecular and Biomedical Sciences Program, Baylor College of Medicine
- Stefan Offermanns
- Department of Pharmacology, Max Planck Institute for Heart and Lung Research
- Didier Y. R. Stainier
- Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
- DOI
- https://doi.org/10.1038/s41467-018-05043-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Tubulogenesis is required for the formation of many internal structures including the trachea. Here, the authors show that the potassium channel KCNJ13 regulates tracheal tube formation, with shorter tracheas forming in mutant mice due in part to changes in actin organization in tracheal smooth muscle cells.
