A method for measuring the distribution of the shortest telomeres in cells and tissues

Tsung-Po Lai; Ning Zhang; Jungsik Noh; Ilgen Mender; Enzo Tedone; Ejun Huang; Woodring E. Wright; Gaudenz Danuser; Jerry W. Shay

doi:10.1038/s41467-017-01291-z

Nature Communications (Nov 2017)

A method for measuring the distribution of the shortest telomeres in cells and tissues

Tsung-Po Lai,
Ning Zhang,
Jungsik Noh,
Ilgen Mender,
Enzo Tedone,
Ejun Huang,
Woodring E. Wright,
Gaudenz Danuser,
Jerry W. Shay

Affiliations

Tsung-Po Lai: Department of Cell Biology, University of Texas Southwestern Medical Center
Ning Zhang: Department of Cell Biology, University of Texas Southwestern Medical Center
Jungsik Noh: Department of Bioinformatics, University of Texas Southwestern Medical Center
Ilgen Mender: Department of Cell Biology, University of Texas Southwestern Medical Center
Enzo Tedone: Department of Cell Biology, University of Texas Southwestern Medical Center
Ejun Huang: Department of Cell Biology, University of Texas Southwestern Medical Center
Woodring E. Wright: Department of Cell Biology, University of Texas Southwestern Medical Center
Gaudenz Danuser: Department of Cell Biology, University of Texas Southwestern Medical Center
Jerry W. Shay: Department of Cell Biology, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-017-01291-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Short telomeres are a hallmark of senescence and can result in genomic instability as well as cancer progression. Here, the authors present TeSLA, a technique to accurately detect telomeres under 1 kb in length.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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