Cardiovascular Diabetology (Nov 2023)

Safety and efficacy of bempedoic acid: a systematic review and meta-analysis of randomised controlled trials

  • Ovidio De Filippo,
  • Fabrizio D’Ascenzo,
  • Mario Iannaccone,
  • Maurizio Bertaina,
  • Attilio Leone,
  • Irene Borzillo,
  • Emanuele Ravetti,
  • Andrea Solano,
  • Ilaria Pagliassotto,
  • Marco Nebiolo,
  • Francesco Bruno,
  • Federico Giacobbe,
  • Saverio Muscoli,
  • Silvia Monticone,
  • Maria Felice Brizzi,
  • Giuseppe Biondi Zoccai,
  • Gaetano Maria De Ferrari

DOI
https://doi.org/10.1186/s12933-023-02022-z
Journal volume & issue
Vol. 22, no. 1
pp. 1 – 15

Abstract

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Abstract Background and aims Bempedoic Acid (BA) is a novel Lipid-Lowering Therapy (LLT). We performed a systematic review and meta-analysis to assess the efficacy and safety of BA in patients with hypercholesterolemia. Methods PubMed, Scopus, and Cochrane library databases were searched for randomised controlled trials evaluating the efficacy and/or safety of BA compared with placebo. Trials investigating dosages other than 180 mg/die were excluded. Major adverse cardiovascular events (MACE) were the primary efficacy endpoint. LDL-cholesterol reduction was the primary laboratory endpoint. Pre-specified safety endpoints included muscle-related adverse events, new-onset diabetes, and gout. The protocol was registered on PROSPERO (temporary ID:399,867). Results Study search identified 275 deduplicated results. 11 studies, encompassing 18,315 patients (9854 on BA vs 8461 on placebo/no treatment) were included. BA was associated with a reduced risk of MACE (OR 0.86, 95% CI 0.79–0.95), myocardial infarction (OR 0.76, 95% CI 0.64–0.88) and unstable angina (OR 0.69, 95% CI 0.54–0.88) compared to control, over a median follow up of 87 (15–162) weeks. BA was associated with a reduction of LDL-Cholesterol (mean difference [MD]–22.42,95% CI − 24.02% to − 20.82%), total cholesterol (− 16.50%,95% − 19.21% to − 13.79%), Apo-B lipoprotein (− 19.55%, − 22.68% to − 16.42%) and high-sensitivity CRP (− 27.83%, − 31.71% to − 23.96%) at 12 weeks. BA was associated with a higher risk of gout (OR 1.55, 95% CI 1.27–1.90) as compared with placebo. Efficacy on laboratory endpoints was confirmed, with a variable extent, across patients on statin or ezetimibe background therapy. Conclusions The improved cholesterol control achieved with BA translates into a reduced risk of MACE, including myocardial infarction and coronary revascularisation. The drug has a satisfactory safety profile except for an increased risk of gout.

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