Revista Brasileira de Reumatologia ()

Recommendations of the Brazilian Society of Rheumatology for the diagnosis and treatment of chikungunya fever. Part 2 - Treatment

  • Claudia Diniz Lopes Marques,
  • Angela Luzia Branco Pinto Duarte,
  • Aline Ranzolin,
  • Andrea Tavares Dantas,
  • Nara Gualberto Cavalcanti,
  • Rafaela Silva Guimarães Gonçalves,
  • Laurindo Ferreira da Rocha Junior,
  • Lilian David de Azevedo Valadares,
  • Ana Karla Guedes de Melo,
  • Eutilia Andrade Medeiros Freire,
  • Roberto Teixeira,
  • Francisco Alves Bezerra Neto,
  • Marta Maria das Chagas Medeiros,
  • Jozélio Freire de Carvalho,
  • Mario Sergio F. Santos,
  • Regina Adalva de L. Couto Océa,
  • Roger A. Levy,
  • Carlos Augusto Ferreira de Andrade,
  • Geraldo da Rocha Castelar Pinheiro,
  • Mirhelen Mendes Abreu,
  • José Fernando Verztman,
  • Selma Merenlender,
  • Sandra Lucia Euzebio Ribeiro,
  • Izaias Pereira da Costa,
  • Gecilmara Pileggi,
  • Virginia Fernandes Moça Trevisani,
  • Max Igor Banks Lopes,
  • Carlos Brito,
  • Eduardo Figueiredo,
  • Fabio Queiroga,
  • Tiago Feitosa,
  • Angélica da Silva Tenório,
  • Gisela Rocha de Siqueira,
  • Renata Paiva,
  • José Tupinambá Sousa Vasconcelos,
  • Georges Christopoulos

DOI
https://doi.org/10.1016/j.rbre.2017.06.004
Journal volume & issue
Vol. 57, no. suppl 2
pp. s438 – s451

Abstract

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Abstract Chikungunya fever has become an important public health problem in countries where epidemics occur because half of the cases progress to chronic, persistent and debilitating arthritis. Literature data on specific therapies at the various phases of arthropathy caused by chikungunya virus (CHIKV) infection are limited, lacking quality randomized trials assessing the efficacies of different therapies. There are a few studies on the treatment of musculoskeletal manifestations of chikungunya fever, but these studies have important methodological limitations. The data currently available preclude conclusions favorable or contrary to specific therapies, or an adequate comparison between the different drugs used. The objective of this study was to develop recommendations for the treatment of chikungunya fever in Brazil. A literature review was performed via evidence-based selection of articles in the databases Medline, SciELO, PubMed and Embase and conference proceedings abstracts, in addition to expert opinions to support decision-making in defining recommendations. The Delphi method was used to define the degrees of agreement in 2 face-to-face meetings and several online voting rounds. This study is part 2 of the Recommendations of the Brazilian Society of Rheumatology (Sociedade Brasileira de Reumatologia - SBR) for the Diagnosis and Treatment of chikungunya fever and specifically addresses treatment.

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