Rationale and design of a multicentre, 12-week, randomised, double-blind, placebo-controlled, parallel-group, investigator-initiated trial to investigate the efficacy and safety of elobixibat for chronic constipation

• Takuma Higurashi,
• Jun Arimoto,
• Atsushi Nakajima,
• Keisuke Ariyoshi,
• Shunsuke Oyamada,
• Masataka Taguri,
• Masato Yoneda,
• Takaomi Kessoku,
• Takashi Kobayashi,
• Anna Ozaki,
• Tomoyuki Iwasaki,
• Takeo Kurihashi,
• Michihiro Iwaki,
• Kunihiro Hosono,
• Eiji Sakai,
• Kosuke Tanaka,
• Atsushi Yamamoto,
• Kota Takahashi,
• Yuki Kasai,
• Tsutomu Yoshihara,
• Noboru Misawa,
• Takayuki Kato,
• Akiko Fuyuki,
• Hideyuki Chiba,
• Machiko Nakatogawa,
• Ayao Suzuki,
• Noritoshi Kobayashi,
• Yasushi Ichikawa

Affiliations

Takuma Higurashi

1 Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan

Jun Arimoto

1 Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan

Atsushi Nakajima

Department of Gastroenterology and Hepatology, Yokohama City University, Yokohama, Kanagawa, Japan

Keisuke Ariyoshi

1 Department of Palliative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Shunsuke Oyamada

6 Japanese Organisation for Research and Treatment of Cancer (JORTC), NPO, Tokyo, Japan

Masataka Taguri

Cardiovascular Center, Sendai Kosei Hospital, Sendai, Miyagi, Japan

Masato Yoneda

Department of Gastroenterology and Hepatology, Yokohama City University, Yokohama, Kanagawa, Japan

Takaomi Kessoku

Department of Gastroenterology and Hepatology, Yokohama City University, Yokohama, Japan

Takashi Kobayashi

Department of Gastroenterology and Hepatology, Yokohama City University, Yokohama, Japan

Anna Ozaki

Department of Gastroenterology and Hepatology, Yokohama City University, Yokohama, Japan

Tomoyuki Iwasaki

Iwasaki Naika Clinic, Yokohama, Japan

Takeo Kurihashi

Department of Internal Medicine, Kanagawa Dental University Yokohama Clinic, Yokohama, Japan

Michihiro Iwaki

Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Kunihiro Hosono

Division of Gastroenterology, Yokohama City University School of Medicine, Yokohama, Japan

Eiji Sakai

Division of Gastroenterology, Yokohama City University School of Medicine, Yokohama, Japan

Kosuke Tanaka

Department of Palliative Medicine, Yokohama City University Hospital, Yokohama, Kanagawa, Japan

Atsushi Yamamoto

Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan

Kota Takahashi

Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan

Yuki Kasai

Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan

Tsutomu Yoshihara

Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan

Noboru Misawa

Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan

Takayuki Kato

Department of Gastroenterology, International University of Health and Welfare Atami Hospital, Atami, Japan

Akiko Fuyuki

Department of Palliative Medicine, Yokohama City University Hospital, Yokohama, Kanagawa, Japan

Hideyuki Chiba

Department of Gastroenterology, Omori Red Cross Hospital, Ota-ku, Japan

Machiko Nakatogawa

Department of Internal Medicine, NamikiKoiso-Medical Clinic, Yokohama, Japan

Ayao Suzuki

Department of Internal Medicine, NamikiKoiso-Medical Clinic, Yokohama, Japan

Noritoshi Kobayashi

Department of Oncology, Yokohama City University Hospital, Yokohama, Kanagawa, Japan

Yasushi Ichikawa

Department of Oncology, Yokohama City University Hospital, Yokohama, Kanagawa, Japan