Diagnostic value of anti-hexokinase 1 and anti-kelch-like 12 antibodies in primary biliary cholangitis patients

Yang Min; Hu Chao; Huang Jun; Fu Ying; Zhang Qi; Cheng Yulan; Lu Jie; Li Guiling; Zhang Jun

doi:10.1515/labmed-2023-0127

Journal of Laboratory Medicine (Jun 2024)

Diagnostic value of anti-hexokinase 1 and anti-kelch-like 12 antibodies in primary biliary cholangitis patients

Yang Min,
Hu Chao,
Huang Jun,
Fu Ying,
Zhang Qi,
Cheng Yulan,
Lu Jie,
Li Guiling,
Zhang Jun

Affiliations

Yang Min: Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University56660, Hangzhou, P.R. China
Hu Chao: School of Basic Medical Sciences, Zhejiang Chinese Medical University, Key Laboratory of Chinese medicine rheumatology of Zhejiang Province, Hangzhou, P.R. China
Huang Jun: Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University56660, Hangzhou, P.R. China
Fu Ying: Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University56660, Hangzhou, P.R. China
Zhang Qi: Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University56660, Hangzhou, P.R. China
Cheng Yulan: Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University56660, Hangzhou, P.R. China
Lu Jie: Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University56660, Hangzhou, P.R. China
Li Guiling: Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University56660, Hangzhou, P.R. China
Zhang Jun: Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University56660, Hangzhou, P.R. China

DOI: https://doi.org/10.1515/labmed-2023-0127
Journal volume & issue: Vol. 48, no. 3
pp. 129 – 135

Abstract

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Anti-mitochondrial antibody (AMA) is not always present in patients with primary biliary cholangitis (PBC). We aimed to determine the additional value of anti-hexokinase 1 (anti-HK1) and anti-kelch-like 12 (anti-KLHL12) antibody in PBC and analyzed the biochemical and immunological parameters of 212 subjects, including PBC patients and healthy controls.

Published in Journal of Laboratory Medicine

ISSN: 2567-9430 (Print); 2567-9449 (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Medicine: Medicine (General): Medical technology
Website: https://www.degruyter.com/view/journals/labm/labm-overview.xml

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