Microfluidic Electrospray Niacin Metal-Organic Frameworks Encapsulated Microcapsules for Wound Healing
Guopu Chen,
Yunru Yu,
Xiuwen Wu,
Gefei Wang,
Guosheng Gu,
Feng Wang,
Jianan Ren,
Huidan Zhang,
Yuanjin Zhao
Affiliations
Guopu Chen
Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
Yunru Yu
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
Xiuwen Wu
Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
Gefei Wang
Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
Guosheng Gu
Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
Feng Wang
Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
Jianan Ren
Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
Huidan Zhang
School of Engineering and Applied Sciences and Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
Yuanjin Zhao
Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
Niacin metal-organic frameworks (MOFs) encapsulated microcapsules with alginate shells and copper-/zinc-niacin framework cores were in situ synthesized by using a microfluidic electrospray approach for wound healing. As the alginate shells were bacteria-responsively degradable, the niacin MOFs encapsulated microcapsules could intelligently, controllably, and programmably release calcium, copper, and zinc ions, depending on the degree of infections. The released ions could not only kill microbes by destroying their membrane and inducing the outflow of nutrient substance, but also activate copper/zinc superoxide dismutase (Cu/Zn-SOD) to eliminate oxygen free radicals and rescue the cells from oxidative stress injury. Furthermore, the simultaneously released niacin could promote hemangiectasis and absorption of functional metal ions. Thus, the niacin MOFs encapsulated microcapsules were imparted with outstanding antibacterial, antioxidant, and angiogenesis properties. Based on an in vivo study, we have also demonstrated that the chronic wound healing process of an infected full-thickness skin defect model could be significantly enhanced by using the niacin MOFs encapsulated microcapsules as therapeutic agent. Therefore, the microfluidic electrospray niacin MOFs encapsulated microcapsules are potential for clinical applications.
