Clinical Review of Eosinophilic Esophagitis

Abstract

Eosinophilic esophagitis is a chronic inflammatory condition characterized by symptoms of esophageal dysfunction and eosinophil infiltration in the esophageal epithelium. The definition of eosinophilic esophagitis continues to evolve, most recently with the characterization of proton pump inhibitor-responsive esophageal eosinophilia. Diagnosis of eosinophilic esophagitis is based on consensus guidelines, but can be challenging because none of the symptoms, endoscopic findings, or histologic features are specific for eosinophilic esophagitis on their own. For treatment, either oral topical corticosteroids or dietary elimination therapy are reasonable first-line options. The choice will depend on both patient preference and clinician expertise. In cases with severe esophageal strictures, dilation is also performed. Proton pump inhibitors play an important role in current management.

Keywords

• Diagnosis
• Eosinophilic esophagitis
• Therapeutics