Frontiers in Aging Neuroscience (Jan 2021)
Early Segmental White Matter Fascicle Microstructural Damage Predicts the Corresponding Cognitive Domain Impairment in Cerebral Small Vessel Disease Patients by Automated Fiber Quantification
- Lili Huang,
- Lili Huang,
- Lili Huang,
- Lili Huang,
- Xin Chen,
- Xin Chen,
- Xin Chen,
- Xin Chen,
- Wenshan Sun,
- Wenshan Sun,
- Wenshan Sun,
- Wenshan Sun,
- Haifeng Chen,
- Haifeng Chen,
- Haifeng Chen,
- Haifeng Chen,
- Qing Ye,
- Qing Ye,
- Qing Ye,
- Qing Ye,
- Dan Yang,
- Dan Yang,
- Dan Yang,
- Dan Yang,
- Mengchun Li,
- Mengchun Li,
- Mengchun Li,
- Mengchun Li,
- Caimei Luo,
- Caimei Luo,
- Caimei Luo,
- Caimei Luo,
- Junyi Ma,
- Junyi Ma,
- Junyi Ma,
- Junyi Ma,
- Pengfei Shao,
- Pengfei Shao,
- Pengfei Shao,
- Pengfei Shao,
- Hengheng Xu,
- Hengheng Xu,
- Hengheng Xu,
- Hengheng Xu,
- Bing Zhang,
- Xiaolei Zhu,
- Xiaolei Zhu,
- Xiaolei Zhu,
- Xiaolei Zhu,
- Yun Xu,
- Yun Xu,
- Yun Xu,
- Yun Xu
Affiliations
- Lili Huang
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Lili Huang
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Lili Huang
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Lili Huang
- Nanjing Neurological Medical Center, Nanjing, China
- Xin Chen
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Xin Chen
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Xin Chen
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Xin Chen
- Nanjing Neurological Medical Center, Nanjing, China
- Wenshan Sun
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Wenshan Sun
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Wenshan Sun
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Wenshan Sun
- Nanjing Neurological Medical Center, Nanjing, China
- Haifeng Chen
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Haifeng Chen
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Haifeng Chen
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Haifeng Chen
- Nanjing Neurological Medical Center, Nanjing, China
- Qing Ye
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Qing Ye
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Qing Ye
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Qing Ye
- Nanjing Neurological Medical Center, Nanjing, China
- Dan Yang
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Dan Yang
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Dan Yang
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Dan Yang
- Nanjing Neurological Medical Center, Nanjing, China
- Mengchun Li
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Mengchun Li
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Mengchun Li
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Mengchun Li
- Nanjing Neurological Medical Center, Nanjing, China
- Caimei Luo
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Caimei Luo
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Caimei Luo
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Caimei Luo
- Nanjing Neurological Medical Center, Nanjing, China
- Junyi Ma
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Junyi Ma
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Junyi Ma
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Junyi Ma
- Nanjing Neurological Medical Center, Nanjing, China
- Pengfei Shao
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Pengfei Shao
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Pengfei Shao
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Pengfei Shao
- Nanjing Neurological Medical Center, Nanjing, China
- Hengheng Xu
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Hengheng Xu
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Hengheng Xu
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Hengheng Xu
- Nanjing Neurological Medical Center, Nanjing, China
- Bing Zhang
- Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
- Xiaolei Zhu
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Xiaolei Zhu
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Xiaolei Zhu
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Xiaolei Zhu
- Nanjing Neurological Medical Center, Nanjing, China
- Yun Xu
- Department of Neurology, Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Yun Xu
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Yun Xu
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Yun Xu
- Nanjing Neurological Medical Center, Nanjing, China
- DOI
- https://doi.org/10.3389/fnagi.2020.598242
- Journal volume & issue
-
Vol. 12
Abstract
Objective: To characterize earlier damage pattern of white matter (WM) microstructure in cerebral small vessel disease (CSVD) and its relationship with cognitive domain dysfunction.Methods: A total of 144 CSVD patients and 100 healthy controls who underwent neuropsychological measurements and diffusion tensor imaging (DTI) examination were recruited. Cognitive function, emotion, and gait were assessed in each participant. The automated fiber quantification (AFQ) technique was used to extract different fiber properties between groups, and partial correlation and general linear regression analyses were performed to assess the relationship between position-specific WM microstructure and cognitive function.Results: Specific segments in the association fibers, commissural WM regions of interest (ROIs), and projection fibers were damaged in the CSVD group [P < 0.05, family-wise error (FWE) correction], and these damaged segments showed interhemispheric symmetry. In addition, the damage to specific tract profiles [including the posteromedial component of the right cingulum cingulate (CC), the occipital lobe portion of the callosum forceps major, the posterior portion of the left superior longitudinal fasciculus (SLF), and the bilateral anterior thalamic radiation (ATR)] was related to the dysfunction in specific cognitive domains. Among these tracts, we found the ATR to be the key set of tracts whose profiles were most associated with cognitive dysfunction. The left ATR was a specific fiber bundle associated with episode memory and language function, whereas the fractional anisotropy (FA) values of the intermediate component of the right ATR were negatively correlated with executive function and gait evaluation. It should be noted that the abovementioned relationships could not survive the Bonferroni correction (p < 0.05/27), so we chose more liberal uncorrected statistical thresholds.Conclusions: Damage to the WM fiber bundles showed extensive interhemispheric symmetry and was limited to particular segments in CSVD patients. Disruption of strategically located fibers was associated with different cognitive deficits, especially the bilateral ATR.
Keywords
- automated fiber quantification
- cerebral small vessel disease
- cognitive decline
- damage mode
- white matter microstructure damage