Nature Communications (Nov 2022)
Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation
- Chengyu Shi,
- Ying Wang,
- Minjie Wu,
- Yu Chen,
- Fangzhou Liu,
- Zheyuan Shen,
- Yiran Wang,
- Shaofang Xie,
- Yingying Shen,
- Lingjie Sang,
- Zhen Zhang,
- Zerui Gao,
- Luojia Yang,
- Lei Qu,
- Zuozhen Yang,
- Xinyu He,
- Yu Guo,
- Chenghao Pan,
- Jinxin Che,
- Huaiqiang Ju,
- Jian Liu,
- Zhijian Cai,
- Qingfeng Yan,
- Luyang Yu,
- Liangjing Wang,
- Xiaowu Dong,
- Pinglong Xu,
- Jianzhong Shao,
- Yang Liu,
- Xu Li,
- Wenqi Wang,
- Ruhong Zhou,
- Tianhua Zhou,
- Aifu Lin
Affiliations
- Chengyu Shi
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Ying Wang
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Minjie Wu
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Yu Chen
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Fangzhou Liu
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Zheyuan Shen
- Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University
- Yiran Wang
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Shaofang Xie
- Key Laboratory of Structural Biology of Zhejiang Province, Westlake Laboratory of Life Sciences and Biomedicine, Westlake University
- Yingying Shen
- Institute of Immunology, Zhejiang University School of Medicine
- Lingjie Sang
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Zhen Zhang
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Zerui Gao
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Luojia Yang
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Lei Qu
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Zuozhen Yang
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Xinyu He
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Yu Guo
- Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University
- Chenghao Pan
- Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University
- Jinxin Che
- Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University
- Huaiqiang Ju
- Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine
- Jian Liu
- Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University
- Zhijian Cai
- Institute of Immunology, Zhejiang University School of Medicine
- Qingfeng Yan
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Luyang Yu
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Liangjing Wang
- Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine and Institute of Gastroenterology, Zhejiang University
- Xiaowu Dong
- Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University
- Pinglong Xu
- MOE Laboratory of Biosystems Homeostasis & Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University
- Jianzhong Shao
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Yang Liu
- Institute of Immunology, Zhejiang University School of Medicine
- Xu Li
- Key Laboratory of Structural Biology of Zhejiang Province, Westlake Laboratory of Life Sciences and Biomedicine, Westlake University
- Wenqi Wang
- Department of Developmental and Cell Biology, University of California
- Ruhong Zhou
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- Tianhua Zhou
- Cancer Center, Zhejiang University
- Aifu Lin
- MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University
- DOI
- https://doi.org/10.1038/s41467-022-34346-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Cancer cells exploit immune checkpoint pathways, such as PD-1/PD-L1, to evade elimination by the immune system. Here, the authors demonstrate that TMUB1 regulates post-translational modifications of PD-L1 and that targeting the TMUB1/PD-L1 interaction promotes anti-tumour T cells responses
