Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
Baptiste Barré,
Laurine Gonnard,
Amandine Guérinot,
Janine Cossy
Affiliations
Baptiste Barré
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI Paris, CNRS, PSL Research University 10, rue Vauquelin 75231 Paris CEDEX 05, France
Laurine Gonnard
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI Paris, CNRS, PSL Research University 10, rue Vauquelin 75231 Paris CEDEX 05, France
Amandine Guérinot
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI Paris, CNRS, PSL Research University 10, rue Vauquelin 75231 Paris CEDEX 05, France
Janine Cossy
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI Paris, CNRS, PSL Research University 10, rue Vauquelin 75231 Paris CEDEX 05, France
(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work concerning the cobalt-catalyzed arylation of iodo-substituted cyclic amines is presented.
