SAGE Open Medicine (Jan 2024)

The effectiveness of single antibiotic paste nitrofurantoin V/S double antibiotic paste in alleviation of post-operative pain of patients suffering from symptomatic irreversible pulpitis—A randomized controlled trial

  • Hira Abbasi,
  • Muhammad Saqib,
  • Afsheen Maqsood,
  • Rizwan Jouhar,
  • Haroon Rashid,
  • Naseer Ahmed,
  • Mohmed Isaqali Karobari,
  • Artak Heboyan

DOI
https://doi.org/10.1177/20503121231220794
Journal volume & issue
Vol. 12

Abstract

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Objective: The present research evaluated and compared effectiveness between nitrofurantoin and double antibiotic paste in alleviating post-operative pain in patients suffering from symptomatic irreversible pulpitis. Methods: There were 60 subjects enrolled who were allotted among three groups: Group 1 – Nitrofurantoin, Group 2 – double antibiotic paste, and Group 3 – Control. Succeeding access opening and chemo mechanical preparation, intracanal medicament was placed in the root canals. Using a numerical pain scale, pain scores were measured at the following time intervals: preoperative, 12, 24, 48, and 72 h. One-way ANOVA and post hoc statistical analysis were conducted, with a p -value of ⩽ considered as statistically significant. Results: Preoperatively, most patients experienced moderate to severe pain. The patients in groups 1 and 2 reported considerable reduction in their pain scores ( p ⩽ 0.001) on each time interval. However, patients in group 3 experienced a higher level of pain even at 72 h. No considerable distinction was found among participant’s pain scores of groups 1 and 2 ( p = 0.193). Conclusion: For effective pain-relieving, both nitrofurantoin and double antibiotic paste can be successfully used in patients suffering from symptomatic irreversible pulpitis. However, when calcium hydroxide was used, patients experience high levels of pain.