Nature Communications (Oct 2018)

Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

  • Zhen Wei,
  • Jinglue Song,
  • Guanghui Wang,
  • Ximao Cui,
  • Jun Zheng,
  • Yunlan Tang,
  • Xinyuan Chen,
  • Jixi Li,
  • Long Cui,
  • Chen-Ying Liu,
  • Wei Yu

DOI
https://doi.org/10.1038/s41467-018-06812-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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Serine hydroxymethyltransferase 2 (SHMT2) converts serine to glycine in mitochondria and is upregulated in a variety of cancers. Here the authors show that acetylation of the lysine-95 (K95) residue negatively regulates SHMT2 expression and activity and is deacetylated by SIRT3 in colorectal cancer.