MicroRNAs from Snellenius manilae bracovirus regulate innate and cellular immune responses of its host Spodoptera litura

Abstract

Tang et al. show that microRNAs derived from an endoparasitic wasp Snellenius manilae bracovirus (SmBV), SmBV-miR-199b-5p and SmBV-miR-2989, target domeless and toll-7 in its host Spodoptera litura, suppressing the innate immune responses of parasitized hosts. This study provides insights into how parasites maximize their fitness by regulating host immunity.