Nature Communications (Jun 2022)

Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse

  • Natàlia Pujol-Gualdo,
  • Kristi Läll,
  • Maarja Lepamets,
  • Estonian Biobank Research Team,
  • Henna-Riikka Rossi,
  • Riikka K. Arffman,
  • Terhi T. Piltonen,
  • Reedik Mägi,
  • Triin Laisk

Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12


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Although pelvic organ prolapse is a common gynecological condition, the genetic component of disease risk is not well known. Here the authors find common genetic variants associated with the disease and present a polygenic risk score to enhance individual risk prediction.