Nature Communications (Oct 2018)

SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells

  • Shuai Wu,
  • Nail Fatkhutdinov,
  • Takeshi Fukumoto,
  • Benjamin G. Bitler,
  • Pyoung Hwa Park,
  • Andrew V. Kossenkov,
  • Marco Trizzino,
  • Hsin-Yao Tang,
  • Lin Zhang,
  • Alessandro Gardini,
  • David W. Speicher,
  • Rugang Zhang

DOI
https://doi.org/10.1038/s41467-018-06656-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ARID1A-mutated ovarian cancer cells.