Nature Communications (Nov 2021)

Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling

  • Dahong Chen,
  • Catherine E. McManus,
  • Behram Radmanesh,
  • Leah H. Matzat,
  • Elissa P. Lei

DOI
https://doi.org/10.1038/s41467-021-26628-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Long-range looping of an enhancer to a promoter (E-P looping) is a key feature of gene activation; thus, regulation of E-P looping could serve as an effective strategy to precisely control gene expression. Here the authors propose the Drosophila chromatin insulator antagonist Shep represses expression of genes during neuronal maturation by preventing E-P looping.