Electrochemical synthesis of heterodehydro[7]helicenes

Abstract

Heterodehydrohelicenes exhibit attractive chiroptical properties, but their direct construction by asymmetric synthesis remains very challenging. Here, the authors report the electrochemical sequential synthesis of azaoxadehydro[7]helicenes from arenols through oxidative hetero-coupling followed by dehydrative cyclization and intramolecular C–C bond formation.