A real-time marker of object-based attention in the human brain. A possible component of a “gate-keeping mechanism” performing late attentional selection in the Ventro-Lateral Prefrontal Cortex
M. Perrone-Bertolotti,
S. El Bouzaïdi Tiali,
J.R. Vidal,
M. Petton,
A.C. Croize,
P. Deman,
S. Rheims,
L. Minotti,
M. Bhattacharjee,
M. Baciu,
P. Kahane,
J.P. Lachaux
Affiliations
M. Perrone-Bertolotti
Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, 38000, Grenoble, France; Institut Universitaire de France (IUF), France; Corresponding author. UFR Sciences de l’Homme et de la Société, Université Grenoble Alpes, CS 40700, 38058, Grenoble Cedex 9, France.
S. El Bouzaïdi Tiali
Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LPNC, 38000, Grenoble, France
J.R. Vidal
UMRS 449, Université Catholique de Lyon, Ecole Pratique des Hautes Etudes, 69002, Lyon, France
M. Petton
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, DYCOG, Lyon, F-69000, France; University of Lyon, Lyon, France
A.C. Croize
INSERM, U836, F-38000, Grenoble, France; Univ. Grenoble Alpes, Institut des Neurosciences, GIN, 38000, Grenoble, France
P. Deman
INSERM, U836, F-38000, Grenoble, France; Univ. Grenoble Alpes, Institut des Neurosciences, GIN, 38000, Grenoble, France
S. Rheims
University of Lyon, Lyon, France; INSERM U1028, CNRS UMR 5292, Lyon’s Neuroscience Research Center, Translational and Integrative Research in Epilepsy, TIGER, Lyon, F-69000, France; Department of Functional Neurology and Epileptology, Hospices Civils de Lyon, Lyon, France
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, DYCOG, Lyon, F-69000, France; University of Lyon, Lyon, France
The decision to process an incoming stimulus attentively - and to trigger a follow-up cascade of high-level processes - is strategic for the human brain as it becomes transiently unavailable to subsequent stimulus processing. In this study, we set to identify brain networks that carry out such evaluations. We therefore assessed the time-course of neural responses with intracerebral EEG in human patients during an attentional reading task, contrasting to-be-attended vs. to-be-ignored items. We measured High-Frequency Activity [50–150 Hz] as a proxy of population-level spiking activity and we identified a crucial component of a Gate-Keeping Mechanism bilateral in the mid-Ventro-Lateral Prefrontal Cortex (VLPFC), at the interplay of the Ventral and Dorsal Attention Networks, that selectively reacts before domain specialized cortical regions that engage in full stimulus analysis according to task demands.
