MMP-2 and MMP-9 gene polymorphisms and risk of head and neck carcinomas

Abstract

Background: Head and neck carcinomas (HNC) account for a majority of ear, nose and throat tumours. They account for 6.3% of all incident malignancies and 6.2 % of all deaths from cancer in Romania in 2020, the fifth most common cancer in this Eastern Europe country. Aim of the study: The aim of our study was to investigate the association between two MMP-2 and MMP-9 promoter gene polymorphisms and head and neck cancer.

Keywords

• risk
• polymorphism
• mmp-9
• mmp-2
• head and neck squamous cell carcinomas