Nature Communications (Sep 2017)
An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model
- Ami Patel,
- Antonio DiGiandomenico,
- Ashley E. Keller,
- Trevor R. F. Smith,
- Daniel H. Park,
- Stephanie Ramos,
- Katherine Schultheis,
- Sarah T. C. Elliott,
- Janess Mendoza,
- Kate E. Broderick,
- Megan C. Wise,
- Jian Yan,
- Jingjing Jiang,
- Seleeke Flingai,
- Amir S. Khan,
- Kar Muthumani,
- Laurent Humeau,
- Lily I. Cheng,
- Leslie Wachter-Rosati,
- C. Kendall Stover,
- Niranjan Y. Sardesai,
- David B. Weiner
Affiliations
- Ami Patel
- The Wistar Institute of Anatomy & Biology
- Antonio DiGiandomenico
- MedImmune
- Ashley E. Keller
- MedImmune
- Trevor R. F. Smith
- Inovio Pharmaceuticals
- Daniel H. Park
- The Wistar Institute of Anatomy & Biology
- Stephanie Ramos
- Inovio Pharmaceuticals
- Katherine Schultheis
- Inovio Pharmaceuticals
- Sarah T. C. Elliott
- The Wistar Institute of Anatomy & Biology
- Janess Mendoza
- Inovio Pharmaceuticals
- Kate E. Broderick
- Inovio Pharmaceuticals
- Megan C. Wise
- The Wistar Institute of Anatomy & Biology
- Jian Yan
- Inovio Pharmaceuticals
- Jingjing Jiang
- Inovio Pharmaceuticals
- Seleeke Flingai
- The Wistar Institute of Anatomy & Biology
- Amir S. Khan
- Inovio Pharmaceuticals
- Kar Muthumani
- The Wistar Institute of Anatomy & Biology
- Laurent Humeau
- Inovio Pharmaceuticals
- Lily I. Cheng
- MedImmune
- Leslie Wachter-Rosati
- MedImmune
- C. Kendall Stover
- MedImmune
- Niranjan Y. Sardesai
- Inovio Pharmaceuticals
- David B. Weiner
- The Wistar Institute of Anatomy & Biology
- DOI
- https://doi.org/10.1038/s41467-017-00576-7
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of infectious diseases. Here, the authors show that two DMAbs targeting Pseudomonas aeruginosa proteins confer protection against lethal pneumonia in mice.
