PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones

Abstract

Degradation of misfolded proteins from the endoplasmic reticulum (ER) is important for maintaining proper cellular protein homeostasis. Here, the authors discovered that the ER membrane protein PGRMC1 binds to misfolded prohormones for recruitment into the ER-phagy degradative pathway.