A study of NLR and it’s correlation with severity and complications of liver cirrhosis on the basis of child turcotte pugh score in a tertiary care hospital, Vijayapur

Abstract

Aim and Objectives: To obtain NLR from complete blood count in patient with liver cirrhosis, to perform Liver function test and clinical examination and obtain CTP score in patient with liver cirrhosis and to evaluate the role of NLR and its correlation with severity and complications of liver cirrhosis on the basis of Child Turcotte Pugh score. Methods: It is a prospective observational study of 90 patients who fulfill inclusion and exclusion criteria and were followed up for one year, evaluated with investigations, includes hematological investigations, ascitic fluid analysis, ultrasound abdomen. Patients who developed complications were identified and correlation with already calculated NLR was done and results were analysed. Results: The blood samples of 90 cirrhosis patients were collected and analysed for NLR and CTP. Out of these patients 20% developed upper GI bleed, 34.4% developed Ascites and 16.67% developed hepatic encephalopathy. There was a positive correlation found between NLR and CTP which was statistically significant (p=0.0001) .Patients with higher NLR were correlated to CTP class B and C thus showing a positive relationship with the severity of disease. Conclusion: This study reveals that there is a statistically significant correlation between NLR and CTP.NLR can be used as a single independent biomarker and simpler scoring system for assessment of severity of liver cirrhosis.

Keywords

• cirrhosis
• neutrophil to lymphocyte ratio
• child turcotte pugh score