Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti

Jinshu Xu; Hiroo Ueno; Chelsea Y. Xu; Binglai Chen; Irving L. Weissman; Pin-Xian Xu

doi:10.1038/ncomms15046

Nature Communications (May 2017)

Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti

Jinshu Xu,
Hiroo Ueno,
Chelsea Y. Xu,
Binglai Chen,
Irving L. Weissman,
Pin-Xian Xu

Affiliations

Jinshu Xu: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Hiroo Ueno: Institute of Stem Cell Biology and Regenerative Medicine, Stanford University
Chelsea Y. Xu: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Binglai Chen: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Irving L. Weissman: Institute of Stem Cell Biology and Regenerative Medicine, Stanford University
Pin-Xian Xu: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/ncomms15046
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 17

Abstract

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The adult mammalian cochlear sensory epithelium consists of mechanosensory hair cells and supporting cells but hair cells cannot regenerate. Here, the authors identify multipotent progenitors that arise fromEya1-expressing otic cells that can regenerate hair cells in mice after 1 week of age.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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