Wound Healing Efficacy of Herbal Ointment Containing  Peristrophe paniculata Forssk. on Incision Wounded  Animals

Abstract

Objective: The present study is aimed to evaluate the curative effect of herbal ointment containing Peristrophe paniculata Forssk. against incision wound. Methods: Animals weighing 150 -200g were divided into five groups each comprising of six rats: Group I served normal control, Group II served as incision wounded control and Group III, IV served as incision wounded animals were treated with 10% and 20% of herbal ointment (HO) containing Peristrophe paniculata Forssk. applied topically for 14 days respectively and group V served as incision wounded animals treated with reference ointment soframycin. The healing of wound was assessed by breaking strength, level of hydroxyproline, hexosamine, tissue and serum protein, ascorbic acid, Deoxyribonucleic Acid (DNA), Ribonucleic Acid (RNA), Superoxide Dismutase (SOD), Lipid Peroxidation (LPO). Results: The topical application of herbal ointment treated groups showed increase in hydroxyproline, hexosamine, protein, breaking strength, DNA, RNA and SOD, Ascorbic acid and significant decrease in the LPO. Conclusion: The results concluded that the Peristrophe paniculata Forssk. has the efficacy in the management of wound healing. Further in-depth studies will be carried out by the isolation of active compounds for drug discovery.

Keywords

• wound
• antioxidants
• herbal ointments
• peristrophe paniculata forssk