Development and validation of prognostic nomogram for T1-3N0M0 non-small cell lung cancer after curative resection
Weijian Mei,
Wang Yao,
Zhengbo Song,
Wenjie Jiao,
Lianxin Zhu,
Qinghua Huang,
Chaolun An,
Jianguang Shi,
Guiping Yu,
Pingli Sun,
Yinbin Zhang,
Jianfei Shen,
Chunwei Xu,
Han Yang,
Qian Wang,
Zhihua Zhu
Affiliations
Weijian Mei
Department of Thoracic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
Wang Yao
Department of Interventional Oncology, The First Affiliated Hospital, Sun Yat-Sen University
Zhengbo Song
Department of Medical Oncology, Cancer Hospital of University of Chinese Academy of Sciences; Zhejiang Cancer Hospital
Wenjie Jiao
Department of Thoracic Surgery, Affiliated Hospital of Qingdao University
Lianxin Zhu
Medical College of Nanchang University
Qinghua Huang
Department of Breast Surgery, Affiliated Tumor Hospital of Guangxi Medical University
Chaolun An
Department of Thoracic Surgery, Nantong Third People’s Hospital Nantong University
Jianguang Shi
Department of Thoracic Surgery, Ningbo First Hospital of Zhejiang University
Guiping Yu
Department of Thoracic Surgery, Affiliated Jiangyin Hospital of Southeast University
Pingli Sun
Department of Pathology Department, The Second Hospital of Jilin University
Yinbin Zhang
Department of Thoracic Surgery, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University
Jianfei Shen
Department of Thoracic Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University
Chunwei Xu
Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Suqian Hospital of Chinese Medicine
Han Yang
Department of Thoracic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
Qian Wang
Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Suqian Hospital of Chinese Medicine
Zhihua Zhu
Department of Thoracic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
Abstract Background Radical resection plus lymph node dissection is a common treatment for patients with T1-3N0M0 non-small cell lung cancer (NSCLC). Few models predicted the survival outcomes of these patients. This study aimed to developed a nomogram for predicting their overall survival (OS). Materials and methods This study involved 3002 patients with T1-3N0M0 NSCLC after curative resection between January 1999 and October 2013. 1525 Patients from Sun Yat-sen University Cancer Center were randomly allocated to training cohort and internal validation cohort in a ratio of 7:3. 1477 patients from ten institutions were recruited as external validation cohort. A nomogram was constructed based on the training cohort and validated by internal and external validation cohort to predict the OS of these patients. The accuracy and practicability were tested by Harrell's C-indexes, calibration plots and decision curve analyses (DCA). Results Age, sex, histological classification, pathological T stage, and HI standard were independent factors for OS and were included in our nomogram. The C-index of the nomogram for OS estimates were 0.671 (95% CI, 0.637–0.705),0.632 (95% CI, 0.581–0.683), and 0.645 (95% CI, 0.617–0.673) in the training cohorts, internal validation cohorts, and external validation cohort, respectively. The calibration plots and DCA for predictions of OS were in excellent agreement. An online version of the nomogram was built for convenient clinical practice. Conclusions Our nomogram can predict the OS of patients with T1-3N0M0 NSCLC after curative resection. The online version of our nomogram offer opportunities for fast personalized risk stratification and prognosis prediction in clinical practice.
