mBio
(Jun 2021)
Increased Production of Outer Membrane Vesicles by Salmonella Interferes with Complement-Mediated Innate Immune Attack
Ruchika Dehinwal,
Danielle Cooley,
Alexey V. Rakov,
Akhil S. Alugupalli,
Joey Harmon,
Olivier Cunrath,
Prashanth Vallabhajosyula,
Dirk Bumann,
Dieter M. Schifferli
Affiliations
Ruchika Dehinwal
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA
Danielle Cooley
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA
Alexey V. Rakov
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA
Akhil S. Alugupalli
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA
Joey Harmon
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Olivier Cunrath
Biozentrum, University of Basel, Basel, Switzerland
Prashanth Vallabhajosyula
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Dirk Bumann
Biozentrum, University of Basel, Basel, Switzerland
Dieter M. Schifferli
ORCiD Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, Pennsylvania, USA
DOI
https://doi.org/10.1128/mBio.00869-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Bacterial outer membrane vesicles (OMVs) mediate critical bacterium-bacterium and host-microbial interactions that influence pathogenesis through multiple mechanisms, including the elicitation of inflammatory responses, delivery of virulence factors, and enhancement of biofilm formation. As such, there is a growing interest in understanding the underlying mechanisms of OMV production.
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