Nature Communications (May 2022)

3D chromatin remodelling in the germ line modulates genome evolutionary plasticity

  • Lucía Álvarez-González,
  • Frances Burden,
  • Dadakhalandar Doddamani,
  • Roberto Malinverni,
  • Emma Leach,
  • Cristina Marín-García,
  • Laia Marín-Gual,
  • Albert Gubern,
  • Covadonga Vara,
  • Andreu Paytuví-Gallart,
  • Marcus Buschbeck,
  • Peter J. I. Ellis,
  • Marta Farré,
  • Aurora Ruiz-Herrera

DOI
https://doi.org/10.1038/s41467-022-30296-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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The role of genome folding in the heritability and evolvability of structural variations is not well understood. Here the authors investigate the impact of the three-dimensional genome topology of germ cells in the formation and transmission of gross structural genomic changes detected from comparing whole-genome sequences of 14 rodent species.