Controllable DNA hybridization by host–guest complexation-mediated ligand invasion

Lin Xiao; Liang-Liang Wang; Chao-Qun Wu; Han Li; Qiu-Long Zhang; Yang Wang; Liang Xu

doi:10.1038/s41467-022-33738-3

Nature Communications (Oct 2022)

Controllable DNA hybridization by host–guest complexation-mediated ligand invasion

Lin Xiao,
Liang-Liang Wang,
Chao-Qun Wu,
Han Li,
Qiu-Long Zhang,
Yang Wang,
Liang Xu

Affiliations

Lin Xiao: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Liang-Liang Wang: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Chao-Qun Wu: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Han Li: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Qiu-Long Zhang: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Yang Wang: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University
Liang Xu: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University

DOI: https://doi.org/10.1038/s41467-022-33738-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Direct dissociation of nucleic acid duplex structures without heating or specific binding proteins is challenging. Here the authors use the cucurbit[7]uril-based host–guest system to construct a ligand-invasion pathway for controllable DNA hybridisation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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