Case Reports in Pediatrics (Jan 2017)

Osteopathic Manipulative Treatment Limits Chronic Constipation in a Child with Pitt-Hopkins Syndrome

  • Alessandro Aquino,
  • Mattia Perini,
  • Silvia Cosmai,
  • Silvia Zanon,
  • Viviana Pisa,
  • Carmine Castagna,
  • Stefano Uberti

DOI
https://doi.org/10.1155/2017/5437830
Journal volume & issue
Vol. 2017

Abstract

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Pitt-Hopkins Syndrome (PTHS) is a rare genetic disorder caused by insufficient expression of the TCF4 gene. Children with PTHS typically present with gastrointestinal disorders and early severe chronic constipation is frequently found (75%). Here we describe the case of a PTHS male 10-year-old patient with chronic constipation in whom Osteopathic Manipulative Treatment (OMT) resulted in improved bowel functions, as assessed by the diary, the QPGS-Form A Section C questionnaire, and the Paediatric Bristol Stool Form Scale. The authors suggested that OMT may be a valid tool to improve the defecation frequency and reduce enema administration in PTHS patients.