Polymorphism Patterns and Socioeconomic Characteristics and Their Influence on the Risk of Preeclampsia
Flavius George Socol,
Marius Craina,
Simona-Alina Abu-Awwad,
Ioana Denisa Socol,
Simona Sorina Farcas,
Ahmed Abu-Awwad,
Denis Serban,
Adina-Ioana Bucur,
Elena Bernad,
Lioara Boscu,
Laura Claudia Popa,
Nicoleta Ioana Andreescu
Affiliations
Flavius George Socol
Doctoral School, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania
Marius Craina
Ist Clinic of Obstetrics and Gynecology, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, Romania
Simona-Alina Abu-Awwad
Ist Clinic of Obstetrics and Gynecology, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, Romania
Ioana Denisa Socol
Doctoral School, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania
Simona Sorina Farcas
Department of Microscopic Morphology—Genetics, Center of Genomic Medicine, University of Medicine and Pharmacy “Victor Babes”, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania
Ahmed Abu-Awwad
Department XV—Discipline of Orthopedics—Traumatology, “Victor Babes” University of Medicine and 21 Pharmacy, 300041 Timisoara, Romania
Denis Serban
Department of Obstetrics and Gynecology, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Adina-Ioana Bucur
Institute of Cardiovascular Diseases Timisoara, 300310 Timisoara, Romania
Elena Bernad
Ist Clinic of Obstetrics and Gynecology, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, Romania
Lioara Boscu
Doctoral School, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania
Laura Claudia Popa
Department of Microscopic Morphology—Genetics, Center of Genomic Medicine, University of Medicine and Pharmacy “Victor Babes”, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania
Nicoleta Ioana Andreescu
Department of Microscopic Morphology—Genetics, Center of Genomic Medicine, University of Medicine and Pharmacy “Victor Babes”, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania
Background: Preeclampsia (PE) is a critical condition affecting pregnancies worldwide. Understanding its etiology, particularly the genetic factors, is vital. This study aims to investigate the association between ACE gene polymorphisms, specifically the ACE G2350A (rs4343) variant, and the predisposition to PE, offering insights into the genetic predisposition towards this complex condition. Methods: A case-control study was conducted with 140 participants without PE (Control Group) and 128 participants diagnosed with PE (PE Group). The study focused on comparing the prevalence of the rs4343 polymorphism between the groups. Results: The analysis identified a significantly reduced risk associated with the AG genotype and an insignificant increase in risk with the AA genotype. Statistically significant differences in demographic and clinical characteristics, such as BMI and marital status, were observed between the groups, suggesting a multifaceted risk profile for PE that includes genetic, environmental, and socio-economic factors. Conclusions: The study highlight the significant role of genetic variations, specifically the ACE G2350A (rs4343) polymorphism, in influencing PE predisposition. It highlights the intricate interplay between genetic predispositions and other risk factors in the development of PE. Further research is encouraged to expand on these findings and explore a wider range of genetic polymorphisms and their interactions with environmental factors.
