Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo

Li-Na Xu; Na Zhao; Jin-Yan Chen; Piao-Piao Ye; Xing-Wei Nan; Hai-Hong Zhou; Qi-Wei Jiang; Yang Yang; Jia-Rong Huang; Meng-Ling Yuan; Zi-Hao Xing; Meng-Ning Wei; Yao Li; Zhi Shi; Xiao-Jian Yan; Xiao-Jian Yan

doi:10.3389/fonc.2019.00002

Frontiers in Oncology (Jan 2019)

Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo

Li-Na Xu,
Na Zhao,
Jin-Yan Chen,
Piao-Piao Ye,
Xing-Wei Nan,
Hai-Hong Zhou,
Qi-Wei Jiang,
Yang Yang,
Jia-Rong Huang,
Meng-Ling Yuan,
Zi-Hao Xing,
Meng-Ning Wei,
Yao Li,
Zhi Shi,
Xiao-Jian Yan,
Xiao-Jian Yan

Affiliations

Li-Na Xu: Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Na Zhao: Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Jin-Yan Chen: Department of Gynecology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Piao-Piao Ye: Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Xing-Wei Nan: Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Hai-Hong Zhou: Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Qi-Wei Jiang: Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Yang Yang: Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Jia-Rong Huang: Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Meng-Ling Yuan: Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Zi-Hao Xing: Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Meng-Ning Wei: Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Yao Li: Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Zhi Shi: Department of Cell Biology and Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
Xiao-Jian Yan: Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Xiao-Jian Yan: Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Women's Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang, China

DOI: https://doi.org/10.3389/fonc.2019.00002
Journal volume & issue: Vol. 9

Abstract

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Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cells in vitro and in vivo is still unclear. In this study, we found that celastrol induced cell growth inhibition, cell cycle arrest in G2/M phase and apoptosis with the increased intracellular reactive oxygen species (ROS) accumulation in ovarian cancer cells. Pretreatment with ROS scavenger N-acetyl-cysteine totally blocked the apoptosis induced by celastrol. Additionally, celastrol inhibited the growth of ovarian cancer xenografts in nude mice. Altogether, these findings suggest celastrol is a potential therapeutic agent for treating ovarian cancer.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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