This research aims determining effect of digital and media activities on media and science literacy of middle-school students and parents and identifying the relationship between them. Quasi- experimental model has been used by which pretest-posttest studies have been held on one group by using quantitative data during research. The sample of the research consists of 60 students and 119 parents who attend a school in the province of Bursa in the academic year of 2013-2014. According to data analysis obtained in the research, there is a significant relation between pretests and posttests about scientific literacy of middle-school students and parents relating to Digital and Media Activities. There is a relation between media and scientific literacy of students and mothers as parents. There is a difference between the applied PISA and TIMSS exams and the students' science literacy. In the light of these results, some suggestion has been offered with regard to focusing on the importance of 21st century skills and literacy, developing scientific and media literacy level and obtaining more comprehensive results.