WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome

Yuyao Tian; Wuming Wang; Sofie Lautrup; Hui Zhao; Xiang Li; Patrick Wai Nok Law; Ngoc-Duy Dinh; Evandro Fei Fang; Hoi Hung Cheung; Wai-Yee Chan

doi:10.1038/s41467-022-33012-6

Nature Communications (Sep 2022)

WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome

Yuyao Tian,
Wuming Wang,
Sofie Lautrup,
Hui Zhao,
Xiang Li,
Patrick Wai Nok Law,
Ngoc-Duy Dinh,
Evandro Fei Fang,
Hoi Hung Cheung,
Wai-Yee Chan

Affiliations

Yuyao Tian: School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong
Wuming Wang: School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong
Sofie Lautrup: Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital
Hui Zhao: School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong
Xiang Li: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Patrick Wai Nok Law: School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong
Ngoc-Duy Dinh: Department of Biomedical Engineering, the Chinese University of Hong Kong
Evandro Fei Fang: Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital
Hoi Hung Cheung: School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong
Wai-Yee Chan: School of Biomedical Sciences, Faculty of Medicine, the Chinese University of Hong Kong

DOI: https://doi.org/10.1038/s41467-022-33012-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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Short stature is a hallmark of Werner Syndrome, but the underlying mechanisms are not well studied. Here they report that WRN regulates bone development and growth by opening SHOX-G-quadruplexes via its helicase activity both in vitro and in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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