Jichu yixue yu linchuang (Dec 2020)
Progress in research on pyroptosis and cardiovascular diseases
Abstract
Pyroptosis is a kind of programmed cell death mediated by the gasdermin protein, including the classical pathway that depends on caspase-1 and the non-classical pathway that depends on caspase-4, -5, and 11, accompanied by the release of a large number of inflammatory factors. Atherosclerosis, myocardial ischemia, heart failure and other cardiovascular diseases are closely related to inflammatory response. Pyroptosis, as a highly pro-inflammatory cell death, is also widely involved in the occurrence and development of the cardiovascular diseases, and plays an important role in these diseases.
