Protein assembly: Controllable design strategies and applications in biology
Yijia Li,
Ruizhen Tian,
Haolu Shi,
Jiayun Xu,
Tingting Wang,
Junqiu Liu
Affiliations
Yijia Li
College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Key Laboratory of Organosilicon Material Technology Zhejiang Province Hangzhou Normal University Hangzhou China
Ruizhen Tian
College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Key Laboratory of Organosilicon Material Technology Zhejiang Province Hangzhou Normal University Hangzhou China
Haolu Shi
College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Key Laboratory of Organosilicon Material Technology Zhejiang Province Hangzhou Normal University Hangzhou China
Jiayun Xu
College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Key Laboratory of Organosilicon Material Technology Zhejiang Province Hangzhou Normal University Hangzhou China
Tingting Wang
College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Key Laboratory of Organosilicon Material Technology Zhejiang Province Hangzhou Normal University Hangzhou China
Junqiu Liu
College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Key Laboratory of Organosilicon Material Technology Zhejiang Province Hangzhou Normal University Hangzhou China
Abstract Protein assembly is the structural basis for the collaboration between proteins to accomplish life activities due to its realization of the domain‐limited and precise spatial arrangement of proteins. Therefore, artificial manipulation of protein self‐assembly has profound implications in areas such as exploring the mysteries of life and developing biomaterials. In this review, we not only summarize the classical assembly strategies and the structures of exquisite protein assemblies, but also aim to generalize the flexible and controllable assembly tools and the “interaction” between the assembled protein‐based materials and the external environment. On the basis of this, the application, challenges and further development of protein assembly in biology are reviewed.
