Uptake of monoaromatic hydrocarbons during biodegradation by FadL channel-mediated lateral diffusion

Kamolrat Somboon; Anne Doble; David Bulmer; Arnaud Baslé; Syma Khalid; Bert van den Berg

doi:10.1038/s41467-020-20126-y

Nature Communications (Dec 2020)

Uptake of monoaromatic hydrocarbons during biodegradation by FadL channel-mediated lateral diffusion

Kamolrat Somboon,
Anne Doble,
David Bulmer,
Arnaud Baslé,
Syma Khalid,
Bert van den Berg

Affiliations

Kamolrat Somboon: School of Chemistry, University of Southampton
Anne Doble: Biosciences Institute, The Medical School, Newcastle University
David Bulmer: Biosciences Institute, The Medical School, Newcastle University
Arnaud Baslé: Biosciences Institute, The Medical School, Newcastle University
Syma Khalid: School of Chemistry, University of Southampton
Bert van den Berg: Biosciences Institute, The Medical School, Newcastle University

DOI: https://doi.org/10.1038/s41467-020-20126-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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The uptake of hydrophobic molecules by bacterial FadL channels is implicated in quorum sensing, interactions with eukaryotic hosts and biodegradation of many pollutants. Insights into monoaromatic hydrocarbon uptake by TodX and CymD channels suggest that all FadL channels mediate substrate uptake via lateral diffusion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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