Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response

Abstract

Abstract After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogestrel (DESO) or levonorgestrel (LEVO). Only two patients became responsive to hypercapnia under treatment, according to their basal vagal heart rate variability. These results suggest that heart rate variability may be promising tool to discriminate patients susceptible to become responsive to hypercapnia under DESO-LEVO treatment. Clinical Trials Identifier NCT01243697

Keywords

• Hypoventilation syndrome
• Desogestrel
• Autonomic nervous system
• Heart rate variability