PLoS ONE (Jan 2013)

Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.

  • Josep M Sierra,
  • Mariana Camoez,
  • Fe Tubau,
  • Oriol Gasch,
  • Miquel Pujol,
  • Rogelio Martin,
  • M Angeles Domínguez

DOI
https://doi.org/10.1371/journal.pone.0059215
Journal volume & issue
Vol. 8, no. 3
p. e59215

Abstract

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Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance.