Facile Electrochemical Sensor for Sensitive and Selective Determination of Guaifenesin, Phenylephrine and Paracetamol on Electrochemically Pretreated Pencil Graphite Electrode
Mihaela Buleandră,
Anca Aurelia Pătrașcu,
Dana Elena Popa,
Iulia Gabriela David,
Irinel Adriana Badea,
Anton Alexandru Ciucu
Affiliations
Mihaela Buleandră
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania
Anca Aurelia Pătrașcu
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania
Dana Elena Popa
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania
Iulia Gabriela David
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania
Irinel Adriana Badea
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania
Anton Alexandru Ciucu
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania
Guaifenesin (GFS), phenylephrine (PHE) and paracetamol (PAR), drugs used in combination for the relief of cold and flu symptoms, were determined at electrochemically pretreated pencil graphite electrode. Differential pulse voltammetry (DPV) was used for the first time for the concomitant determination of the target compounds based on the electro-oxidation of PAR at 0.43 V, PHE at 0.74 V and GFS at 1.14 V in Britton–Robinson buffer pH 6.0. Under optimized experimental conditions, two linear ranges were obtained for PAR (2.50 × 10−6 M–1.00 × 10−5 M and 1.00 × 10−5 M–1.00 × 10−4 M) and for PHE and GFS linearity was proved between 5.00 × 10−6 M–2.00 × 10−4 M and 2.50 × 10−6 M–2.00 × 10−4 M, respectively. The detection limits were 8.12 × 10−7 M for PAR, 1.80 × 10−6 M for PHE and 8.29 × 10−7 M for GFS. The selective and sensitive DPV method and the electrochemically treated electrode were employed for simultaneous analysis of the analytes in pharmaceutical samples with good recoveries.
