Succinimides: Synthesis, properties and anticonvulsant activity

Abstract

Succinimide is a cycle imide of succinic acid that is present in numerous biologically active compounds including anticonvulsants, antitremor, anti-Parkinson`s agents. This paper describes different ways of synthesis of succinimide-derivatives their physical properties and reactivity. Also, the most widely used succinimide anticonvulsants and the analysis of structure-activity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.

Keywords

• succinimide
• properties
• reactivity
• sythesis
• zarontin
• celontin
• milontin
• anticonvulsant activity
• pharmacofor model
• lipophilicity
• hydrogen bonding