Immune modulation of liver sinusoidal endothelial cells by melittin nanoparticles suppresses liver metastasis

Xiang Yu; Lu Chen; Jianqiao Liu; Bolei Dai; Guoqiang Xu; Guanxin Shen; Qingming Luo; Zhihong Zhang

doi:10.1038/s41467-019-08538-x

Nature Communications (Feb 2019)

Immune modulation of liver sinusoidal endothelial cells by melittin nanoparticles suppresses liver metastasis

Xiang Yu,
Lu Chen,
Jianqiao Liu,
Bolei Dai,
Guoqiang Xu,
Guanxin Shen,
Qingming Luo,
Zhihong Zhang

Affiliations

Xiang Yu: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology
Lu Chen: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology
Jianqiao Liu: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology
Bolei Dai: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology
Guoqiang Xu: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology
Guanxin Shen: Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology
Qingming Luo: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology
Zhihong Zhang: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-019-08538-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Liver sinusoidal endothelial cells are known to promote immune tolerance in liver. Here, the authors target these cells using melittin nanoparticles and show alterations in the liver immune environment and suppression of liver metastases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal